Ekholm, 34, has been out since March 4 with an undisclosed injury, missing six games.
The defenceman has 27 points (eight goals, 19 assists) in 60 games this season.
Hyman, 32, missed Sunday’s game against the New York Rangers, also with an undisclosed injury.
The winger has 37 points (22 goals, 15 assists) in 61 games.
Catch the Oilers opening their four-game homestand against Utah on Sportsnet One and Sportsnet+ starting at 7 p.m. MT / 9 p.m. ET.